The supplement aisle sells longevity by the bottle. We read the human trials — not the mouse hype — and sort the compounds with real evidence from the ones riding a viral wave. Below, every supplement guide on the site, grouped by what it actually does.
Almost every anti-aging supplement follows the same arc: a striking result in mice or a petri dish, a wave of influencer marketing, then years of slower, messier human data that rarely match the headline. Our approach is simple — we start from the randomised controlled trials, note where the evidence is genuinely strong (omega-3, creatine, protein basics), where it is promising but early (NAD+ precursors, spermidine, urolithin A), and where the marketing has run well ahead of the science (many peptides, most "reversal" claims). Every claim on these pages is cited to peer-reviewed research, and each guide is checked against our editorial and fact-checking policy.
How to use this hub: the guides are grouped by what each compound actually targets. The NAD+ family (NAD+, NMN, NR) is about the coenzyme your cells run on and whether precursors can restore it. The compounds section covers the molecules behind most longevity headlines — spermidine and autophagy, resveratrol and sirtuins, urolithin A and mitochondria, plus taurine, omega-3, creatine and the newer fats. Peptides and skin gathers BPC-157, copper peptides and collagen, while the drugs section handles rapamycin and senolytics, where the animal data are striking but the human evidence is still thin.
Two honest caveats run through all of it. First, no pill has been shown to extend human lifespan; the strongest longevity evidence still belongs to sleep, exercise and diet — see our longevity habits guide. Second, dose, purity and third-party testing matter as much as the molecule itself. Use these guides to decide what is worth your money, then talk to a clinician before you start. If you just want the short list, jump to the supplements actually worth your money.
The autophagy trigger found in wheat germ and aged cheese — and what the human data really support.
Where to get it from food, how much matters, and the safety picture in plain terms.
The compound that launched the sirtuin craze, assessed against what human trials actually found.
A gut-made metabolite that clears worn-out mitochondria — one of the better-evidenced newcomers.
An obscure antioxidant that falls with age and made mice live longer. The honest science.
A top journal called it a driver of aging. The animal data dazzle; the human data are contested.
One of the very few supplements to move a validated aging clock in a real randomised trial.
Glycine plus NAC to rebuild the body's master antioxidant — the promising, still-small evidence.
Famous for muscle, but the research on the aging brain may be the more interesting story.
A dairy fat we were told to avoid, now pitched as the first new essential fatty acid in 90 years.
A daily multivitamin nudged five aging clocks in a 958-person Harvard trial — real, and smaller than the headlines.
Extra klotho lengthens life in mice and low levels predict earlier death in people — plus how exercise raises your own.
The 'Wolverine peptide' is everywhere in clinics and forums. The honest evidence — and the human data gap.
What the research on this skincare-and-repair peptide supports, and where marketing runs ahead.
For once the buzzword has a real stack of human trials behind it — here's what they show for skin.
Beyond skin — what collagen does and doesn't do for the rest of your aging body.
Stunning animal data, real human risks, and what we still don't know about the field's headline molecule.
Fisetin and quercetin promise to clear senescent cells — the theory, and how thin the human evidence still is.
TikTok's favourite resin has a $200m market and exactly seven human trials. What shilajit does for testosterone, bone and muscle — and what it doesn't.
A viral supplement, AKG, is now tied to reversing biological age. The honest science: the Rejuvant data, the new 2026 cohort, and the human trial to watch.
Cis-15-tetracosenoic acid, better known as nervonic acid (C24:1 n-9), is the fatty acid of myelin. What the brain-health evidence actually shows.
Mice fed less valine lived 23% longer — males only. What the 2026 Nature Aging study really means for BCAA supplements, protein and muscle after 40.
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