The foundations: how aging is measured, which interventions have human data, and where the field is still guessing in public.
This is the hub for the questions underneath everything else. How is aging actually measured, now that epigenetic clocks and blood-marker scores give a number that is not your birthday? What does that number mean, given that different organs and even different cell types in the same body appear to age at different rates? And which of the interventions that dominate longevity headlines have been tested in people at all?
The guides below cover the measurement side - epigenetic clocks, the PhenoAge blood markers, what biological age reversal claims rest on - and the intervention side, from rapamycin and senolytics through cellular reprogramming and plasma exchange to the first human trials now underway. They also cover the parts of aging that are not optional: immune decline, thymus involution, gut microbiome shifts, heat tolerance, and environmental exposures such as microplastics.
Running through all of it is the same ranking. The interventions with the strongest human evidence are still sleep, movement, diet quality and not smoking, which is why the habits guide sits in this topic rather than off to one side. Drug and clinic-based approaches are covered because they are genuinely interesting, not because the evidence is settled. Everything is cited to peer-reviewed research, and none of it is medical advice.
Related topics: Longevity supplements · NAD+ and NMN · Brain health and cognition · Muscle, strength and fitness
The daily habits with the strongest longevity evidence — VO2 max, sleep, protein, sauna and fasting. Start the free basics that beat any pill today.
Longevity clinics promise to reverse your biological age. Here's what the real trials — diet, calorie cutting, epigenetic clocks — actually show, honestly.
A 2026 Berlin study pitted 14 aging biomarkers against death — the epigenetic clock won. What the pace-of-aging test really measures, and its limits.
The nine PhenoAge blood markers in plain English: albumin, creatinine, glucose, CRP, lymphocytes, MCV, RDW, ALP and WBC — what values indicate.
A 2026 Nature Communications study found cells in one tissue age at very different rates. What that means for biological age tests — and what it doesn't.
Scientists just dosed the first human with a cellular reprogramming therapy built to reverse aging. What ER-100 and the OSK Yamanaka factors really mean.
A 2026 study puts the maximum human lifespan near 156 years — set by DNA damage in cells that never divide. What that number actually means for you.
Scientists screened 6,442 existing drugs against the hallmarks of aging. 21 look pro-longevity, 23 look age-accelerating. What that really means.
Rapamycin is the most reproducible lifespan-extending drug in animals. What the PEARL trial, Dog Aging Project and human data show — plus caveats.
Senolytics promise to clear aging "zombie" cells with fisetin and quercetin. What the small human trials show — and what is still mouse hype.
A 2025 trial found therapeutic plasma exchange rejuvenated 15 epigenetic clocks. The honest science on whether swapping your blood plasma can slow aging.
Your immune system ages too — a process called immunosenescence. Here's what inflammaging is, the warning signs, and what actually slows immune aging.
Your thymus starts shrinking in your first year of life and drives immune aging. What the TRIIM trial really showed — and the race to regrow it.
Plastic is in human brains, arteries and blood. What the 2024–2026 studies on microplastics and aging really prove — plus 3 habits that cut exposure.
Core temperature climbs 0.08°C per decade in extreme heat, starting in your 20s. Two 2026 studies show the decline is real — and partly trainable.
Frequent sauna use is linked to lower cardiovascular and all-cause mortality in landmark Finnish data. What studies on heart, brain and vessels show.
Do your gut bacteria decide how you age? What centenarian microbiomes and the 'longevity bug' Akkermansia really show — plus what actually helps.
Fibermaxxing is TikTok's biggest longevity trend — piling on 50g+ of fiber a day. Here's what the science really says and how much fiber you actually need.
Does intermittent fasting really beat just eating less? We put the human trials head-to-head — why calories and adherence beat the clock. See the verdict.
Free biological age calculator: a 60-second lifestyle estimate plus the Levine PhenoAge blood-test formula from nine markers.
Score your daily habits 0–100 and get a letter grade plus your top 3 highest-impact gaps to fix. Free, science-based, no sign-up. From Anti-Aging Daily.
Calculate your weekly sleep debt from weeknight and weekend sleep. Free, science-based, no sign-up. See how many hours you're short and why it matters.
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